Interferon alpha-2 enhances slow-wave sleep in rabbits
Identifieur interne : 000B52 ( Main/Exploration ); précédent : 000B51; suivant : 000B53Interferon alpha-2 enhances slow-wave sleep in rabbits
Auteurs : James M. Krueger [États-Unis] ; Charles A. Dinarello [États-Unis] ; Shai Shoham [États-Unis] ; Damien Davenne [États-Unis] ; James Walter [États-Unis] ; Sandra Kubillus [États-Unis]Source :
- International Journal of Immunopharmacology [ 0192-0561 ] ; 1987.
English descriptors
- Teeft :
- Average voltage, Average voltages, Beta frequency band, Body movement, Body temperature, Brain temperature, Brain temperature changes, Brain temperatures, Cerebrospinal fluid, Control recordings, Control solutions, Control values, Delta wave voltages, Dinarello, Effective dose, Endogenous pyrogen, Endotoxin, Experimental conditions, Experimental control, Experimental procedures, Febrile, Febrile responses, Fever responses, Frequency band, Frequency bands, Glial cell products, Immune, Immune regulation, Immune response, Individual values, Infusion, Interferon, Krueger, Muramyl, Muramyl dipeptide, Muramyl peptides, Other frequency bands, Pappenheimer, Peptide, Physiol, Pmxb, Polygraph records, Polypeptide release, Present study, Prostaglandin, Recording periods, Same rabbits, Second hour, Significant difference, Significant reduction, Slow wave, Slow wave activity, Slow waves, Temperature regulation, Time course, Time courses.
Abstract
Abstract: Interferon alpha-2 (IFN) is a leukocyte product with several biological properties including antiviral activity, pyrogenicity and enhancement of immune functions. We report here that an additional facet of IFN activity is its ability to enhance slow-wave sleep (SWS) without greatly altering other aspects of sleep. Intravenous or cerebral intraventricular injections of human IFN into rabbits induced enhancement of SWS, electroencephalographic slow-wave (0.5 – 4 Hz) activity and brain temperatures. IFN induced slight reductions in rapid-eye movement sleep. Animal behavior, brain temperature changes that occur during the transition from one arousal state to another, and the cyclic nature of states of vigilance remained undisturbed after IFN treatment. The sleep-promoting activity of IFN may be related to feelings of lassitude and sleepiness that often accompany viral disease and interferon therapy. That IFN and other immunoactive substances, e.g. interleukin-1 and muramyl peptides, can enhance sleep suggests that sleep is linked into the immune response.
Url:
DOI: 10.1016/0192-0561(87)90107-X
Affiliations:
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We report here that an additional facet of IFN activity is its ability to enhance slow-wave sleep (SWS) without greatly altering other aspects of sleep. Intravenous or cerebral intraventricular injections of human IFN into rabbits induced enhancement of SWS, electroencephalographic slow-wave (0.5 – 4 Hz) activity and brain temperatures. IFN induced slight reductions in rapid-eye movement sleep. Animal behavior, brain temperature changes that occur during the transition from one arousal state to another, and the cyclic nature of states of vigilance remained undisturbed after IFN treatment. The sleep-promoting activity of IFN may be related to feelings of lassitude and sleepiness that often accompany viral disease and interferon therapy. That IFN and other immunoactive substances, e.g. interleukin-1 and muramyl peptides, can enhance sleep suggests that sleep is linked into the immune response.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Krueger, James M" sort="Krueger, James M" uniqKey="Krueger J" first="James M." last="Krueger">James M. Krueger</name></region><name sortKey="Davenne, Damien" sort="Davenne, Damien" uniqKey="Davenne D" first="Damien" last="Davenne">Damien Davenne</name><name sortKey="Dinarello, Charles A" sort="Dinarello, Charles A" uniqKey="Dinarello C" first="Charles A." last="Dinarello">Charles A. Dinarello</name><name sortKey="Kubillus, Sandra" sort="Kubillus, Sandra" uniqKey="Kubillus S" first="Sandra" last="Kubillus">Sandra Kubillus</name><name sortKey="Shoham, Shai" sort="Shoham, Shai" uniqKey="Shoham S" first="Shai" last="Shoham">Shai Shoham</name><name sortKey="Walter, James" sort="Walter, James" uniqKey="Walter J" first="James" last="Walter">James Walter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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